Molecular Diagnostics Program in the Division of Public Health Sciences

Molecular Pathology and Biomarkers

We are interested in the discovery and development of novel biomarkers that are related to the prevention, treatment, and prognostication of prostate cancer. The ultimate goal is to improve personalized cancer treatment and prevention approaches for prostate cancer. We are utilizing primary cell culture systems that recapitulate normal and cancerous human prostate tissues to accelerate the translation of molecular discoveries.

Research in Prostate Cancer Metastasis
Our research in prostate cancer metastasis concentrates on the activity of the HGF/c-MET axis, epithelial-to-mesenchymal transition and stromal-epithelial interactions.

Research in Prostate Cancer Prevention
Our research in prostate cancer prevention focuses on the molecular consequences of ingestion of sulforaphane, the active ingredient in broccoli.

Biospecimen Science
To extend the benefits of targeted cancer treatments to the broader community, we develop better tools for procuring and analyzing formalin-fixed tissues and take an active role in tissue harvesting efforts by the prostate and ovarian SPORE programs.